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Answer (1 of 2): It’s very hard to say “which is better” because one may work extremely well for one person and the other way around. Common interactions include sinusitis among females and nephrolithiasis among males. Sertraline's interaction with any of these substances may enhance or decrease the effect of the drug. Evidence shows that Adderall, for most people, does cause a longer-lasting, non-jittery period of focus than caffeine does.