It will have been given to you to help keep your mood within normal limits by helping to control the episodes of mania. Abbott Chem. Patients receiving daily doses higher than 45 mg/kg/day body weight should be carefully monitored. The generally accepted therapeutic range for total valproic acid steady-state concentrations is 50–100 μg/mL, although some clinicians suggest drug concentrations as high as 175 μg/mL.